Adding, Deleting and Moving Guides
Here are a few snippets of VBA you can use to modify guides in those versions of PowerPoint that support this sort of thing (2016 and possible 2013, not 2010 and earlier).
Note: all measurements are in Points. There are 72 points per inch.
Add Guides
Sub AddGuides()
With ActivePresentation.Guides
' Add a vertical guide at 2" from left
.Add ppVerticalGuide, 144
' Add a horizontal guide at 1" from left
.Add ppHorizontalGuide, 72
End With
End Sub
Move Guides
Sub MoveGuides()
With ActivePresentation.Guides
' Move the second guide to 5" from left or top
' depending on whether it's vertical or horizontal
.Item(2).Position = 5 * 72
End With
End Sub
Delete Guides
Sub DeleteGuides()
With ActivePresentation.Guides
' Delete the second guide
.Item(2).Delete
End With
End Sub
See How do I use VBA code in PowerPoint? to learn how to use this example code.